Human Herpesviruses 6 & 7
HHV-6b variant:
Commonly infects children.
Produces a rash called exanthema subitum, aka, roseola, which lasts 24-48 hours.
Some children may also experience febrile seizures or other problems.
The virus replicates and sheds in the
salivary glands
In the histological sample, we can see examples of nuclear and cytoplasmic inclusion bodies in infected cells.
Following resolution of primary infection, HHV-6 produces latent infection in T-cells.
However, in immunocompromised patients, infection can have multi-organ effects and even lead to death
— It is also thought to be a co-factor in AIDS progression.
Human herpes virus 7
- Common childhood infection, typically acquired later than HHV-6.
Infection is typically asymptomatic; can present with rash like HHV-6.
