- Aka, “Non-A, Non-B Enteric/Epidemic” hepatitis.
- Positive-sense RNA Hepevirus with an enveloped icosahedral capsid.
- Transmitted via the fecal-oral route.
– Epidemics are associated with
contaminated water supply.
- Acute hepatitis with resolution.
Exception: Mortality is high among pregnant (“Expecting”) women*
– Especially during the third trimester, when
fulminant hepatitis is most likely to develop.
- Many authors state that HEV only causes acute hepatitis; however, some evidence suggests that Genotype 3 causes chronic hepatitis in immunosuppressed individuals.
- No vaccine
- Prevention includes thorough sanitation, particularly of water supplies
- Treatment = supportive care.
Hepatitis A
Hepatitis B
Hepatitis C
Hepatitis D
Cullen, John M., and Stanley M. Lemon. “Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection.” Cold Spring Harbor Perspectives in Medicine, April 30, 2018, a033456. https://doi.org/10.1101/cshperspect.a033456.
Drebber, Uta, Margarete Odenthal, Stephan W. Aberle, Nadine Winkel, Inga Wedemeyer, Jutta Hemberger, Heidemarie Holzmann, and Hans-Peter Dienes. “Hepatitis E in Liver Biopsies from Patients with Acute Hepatitis of Clinically Unexplained Origin.” Frontiers in Physiology 4 (December 13, 2013). https://doi.org/10.3389/fphys.2013.00351.
Kasper, Dennis L., Stephen Hauser L., Larry Jameson J., Anthony S. Fauci, Dan Longo L., and Joseph Loscalzo. Harrison’s Principles of Internal Medicine. 19th ed. McGraw-Hill Education, 2015.
Levinson, W. Review of Medical Microbiology & Immunology. 14th ed. McGraw-Hill Education, 2016.
Lo Re, Vincent. “Extrahepatic Complications of Hepatitis C Virus Infection in HIV and the Impact of Successful Antiviral Treatment.” Clinical Infectious Diseases 64, no. 4 (February 15, 2017): 498–500. https://doi.org/10.1093/cid/ciw814.
“WHO | What Is Hepatitis?” WHO. Accessed August 29, 2018. http://www.who.int/features/qa/76/en/.
