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Mitosis

Mitosis

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Somatic cells
• Most of the body's cells • Diploid (2n) : 46 chromosomes
Reproductive cells: gametes
• Sperm and egg cells • Haploid (1n): 23 chromosomes
Interphase
• Cell doubles in size and DNA during interphase • 90-95% of cell cycle • G1: cell grows without replicating DNA • S: synthesis phase, DNA replicates • G2: cell synthesizes proteins in preparation for mitosis • Chromosomes condensed during mitosis: uncondensed (chromatin form) for rest of cell cycle
  • Somatic cell division
Prophase
• Centrosomes migrate to opposite sides of cell • Mitotic spindles form from centrosomes
Prometaphase
• Nuclear envelope fragments • Nucleolus disappears • Sister chromatids attached to each other at their centromeres until anaphase
Metaphase
• Chromosomes line up at metaphase plate
Anaphase
• Sister chromatids move to opposite sides of cell
Telophase
• Nuclear envelope reforms
Cytokinesis
• Cytoplasm divides cell into two • Produces 2 diploid daughter cells with identical genomes
Mitosis
• Division of nucleus into 2 daughter nuclei
Cytokinesis
• Division of cytoplasm
CLINICAL CORRELATION
Aneuploidy
• Sister chromatids do not separate properly during cell division (mostly meiosis but also occurs during mitosis) • Daughter cells with extra or missing chromosome • Common in cancer cells