Q. A 28-year-old male was admitted yesterday for a persistent cough, shortness of breath, and fatigue. No focal signs of infection were identified, though a chest x-ray showed increased lung markings, hyperinflation, and bullae. Laboratory studies revealed a normal complete blood count, and his chemistry panel showed elevated liver enzymes. The patient has no known medical history. He works at a restaurant and denies known occupational exposure. He reports drinking “socially”, and has a 5-pack-year history of smoking. This morning, staff report the patient has done well overnight with no new symptoms. On physical examination, he is afebrile, blood pressure is 132/85 mm Hg, respiratory rate 18/min, heart rate 70/min, and oxygen saturation is 98 percent on room air. Auscultation of his lungs demonstrates expiratory wheezing, ronchi, and fine crackles in both lung fields. His cardiac examination is within normal limits. You detect a moderately enlarged liver, and otherwise his abdomen is soft and nontender. A chest CT was performed earlier today (see image). Based on the information you have at this point in time, what is the most likely diagnosis?

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