Q. A 54-year-old woman who was diagnosed with dermatomyositis (based on clinical, lab tests, and biopsy findings) about three months ago came to your office for her routine follow-up. In her last follow-up one month ago, her muscle forces were improving, and she had no new skin rash. Her lab tests showed near-normal serum creatine kinase, normal ESR, CRP, and complete blood count (CBC). She receives prednisone 25 mg/day. Today, she complains of worsening weakness and muscle pain. The temperature is 37.5 degrees Celsius (99.5 degrees Fahrenheit). The physical exam reveals a mild weakness in the proximal muscles of the lower and upper limbs. The new lab tests show:
Blood:
Leukocyte count (WBC) 8,500/mm3
Neutrophils, segmented 52%
Neutrophils, bands 3%
Lymphocytes 38%
Monocytes 6%
Eosinophils 1%
Creatine kinase: 230 U/L
ESR: 18 mm/h
CRP: 0.6 mg/dL
What is the best plan for her now?