Q. A 56-year-old man has brought to the emergency department with a two-week history of fatigue, low-grade fever, and unexplained weight loss. Recently he has had bouts of night sweats and intermittent, non-radiating chest discomfort that is not associated with exertion or meals. He has also noticed small, tender, red bumps on his fingers and toes and painless reddish spots on the palms of his hands and soles of his feet. He has a past medical history of intravenous drug use and has been sober for ten years. He does not take any regular medications and has not had any recent dental work or procedures. His vitals include a temperature of 38.3°C, blood pressure of 130/85 mmHg, pulse of 88/min, and oxygen saturation of 95% on room air. Physical examination reveals a new holosystolic murmur best heard at the apex. Lab investigations show a white blood cell count of 12,000/mm3 and ESR of 45 mm/hr. Blood cultures drawn from different sites are pending. ECG and chest x-ray are unremarkable. What is the most appropriate next step of the management in this case?