Q. A 7-year-old male presents to the emergency department with a fever of 102 degrees Fahrenheit and a cough that has been ongoing for the past week. His mother also states he has an infection on his left thumb as well. His medical history is significant for a history of recurrent bacterial infections, particularly involving his skin and respiratory tract. On physical examination, the patient appears ill and is noted to be tachycardic with a heart rate of 130/min. You appreciate a 1 cm pyogenic granuloma on the dorsal aspect of his left thumb overlying the proximal interphalangeal joint (see image). His lungs have diffuse crackles on auscultation, and he has a decreased oxygen saturation of 88 percent on room air. His chest X-ray shows bilateral infiltrates, consistent with pneumonia. Blood tests reveal an elevated white blood cell count of 15,000/mm3, with a neutrophil predominance. The patient's C-reactive protein level is markedly elevated at 12 mg/dL. Serum levels of all immunoglobulins are within the normal range. You start the patient on broad-spectrum antibiotics, including intravenous vancomycin and cefepime. He is also given supplemental oxygen via nasal cannula and is monitored closely for respiratory distress. Further investigations, including a chest CT scan and bronchoscopy, revealed the presence of multiple pulmonary granulomas. You adjust the patient's antibiotic regimen to include antifungal therapy to cover possible fungal infections. The patient remains hospitalized for several days, receiving intravenous antibiotics and oxygen therapy. He gradually improves, and his oxygen saturation levels returned to normal. Along with continued immunoglobulin replacement therapy, which of the following antibacterial and antifungal prophylaxis regimens is most appropriate for this patient?

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