Q. A 52-year-old woman comes to the physician’s office for dry mouth and dryness in both eyes for the past 1 year. She has a constant feeling of something like sand in her eyes. And also because of her dry mouth, she finds it hard to eat solid food without drinking water. She is a non-smoker, non-alcoholic, and not taking any drugs. She reached menopause a year ago.
Her temperature is 99.8°F (37.6°C), pulse is 90/min, blood pressure is 130/80 mmHg, and respirations are 14/min. Physical examination shows non-tender bilateral parotid gland enlargement. Oral examination shows multiple caries teeth. Slit lamp examination shows bilateral small corneal ulcerations with rose bengal stain.
Which of the following antibodies would most likely be present on further testing in this patient based on her clinical features?