Q. A 22-year-old Syrian man comes to the clinic because of fatigue and difficulty breathing. He emigrated to the US last month, he mentions that he was diagnosed in Syria with hematologic disease, he does not remember the name of his diagnosis but he was receiving blood transfusion every 7 weeks. In cytogenetic studies, there is a point mutation at the promoter site of both alleles of a gene on chromosome 11. There is hepatosplenomegaly on clinical examination. Which of the following will be consistent with this patient's condition?