Q. A 45-year-old male presents to your clinic with a chief complaint of abdominal pain and diarrhea. The patient reports the symptoms have been ongoing for the past two weeks and have been increasing in intensity. He denies any fevers, known sick contacts, or recent travel. He also reports a history of irritable bowel syndrome diagnosed by his primary care physician 10 years ago. He is currently not on any medication for this condition. He also has a past medical history of asthma, for which he is currently taking albuterol as needed. The patient is married and works as a teacher. He has no known drug allergies, and denies the use of alcohol or tobacco. On physical examination, the patient is found to be in no acute distress. His abdomen is mildly tender to palpation in the left lower quadrant, with mild diffuse abdominal distention. You detect hyperactive bowel sounds. No rebound tenderness or guarding is appreciated. There is an erythematous macular rash on his feet bilaterally (see image) with apparent evolution into purpuric papules and papulopustules. You obtain a stool sample and schedule the patient for blood work and a colonoscopy. Based on the information you have at this point in time, which of the following additional findings would be most supportive of a diagnosis of Crohn’s disease versus ulcerative colitis?

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