Q. A 60-year-old male presents to the emergency department for evaluation of persistent dysphagia that has been present for the past three months. The patient reports a gradual onset of difficulty swallowing both solid and liquid foods, which has progressively worsened over time. He denies any associated chest pain, regurgitation, or weight loss. On physical examination, the patient appears thin but is otherwise healthy-looking. You detect no palpable masses in his neck or supraclavicular region. Vital signs were within normal limits. A barium swallow is performed (see image), which reveals a stricture in the distal esophagus, causing a delay in the progression of barium into the stomach. An upper endoscopy is subsequently performed, and biopsy samples are obtained from the strictured area. Pathological examination of the biopsy samples reveals adenocarcinoma of the esophagus. The tumor is located in the distal esophagus and is considered to be at an advanced stage, with involvement of the muscularis propria. Overexpression of the protein from which of the following genes is implicated in tumor invasion and lymph node metastasis, and associated with poorer survival from this cancer?