Q. A 16-year-old girl comes to the physician’s office for burning micturition, vaginal itching, and vaginal discharge for the past 1 week. She denies recent fever, back pain, hematuria, or vaginal bleeding. She has been sexually active with multiple partners and uses protection irregularly. Her last menstrual period was a week ago. She attained menarche at the age of 12 years.
Her temperature is 98.4°F (37°C), pulse is 90/min, blood pressure is 110/80 mmHg, and respirations are 14/min. Physical examination shows mucopurulent vaginal discharge and the cervix looks friable. A pregnancy test is negative. Nucleic acid amplification testing of vaginal discharge is positive for Neisseria gonorrhoeae.
Which of the following treatment regimen is most appropriate for this patient?