Q. A 61-year-old female presents to neurology clinic with concerns for cognitive impairment. During the last year, her husband notes that she has difficulties with following commands, paying bills, driving, and following through on tasks. In addition, her husband notes that she endorses seeing small children and animals in the living room that did not exist. He no longer sleeps in the same bed with the patient due to constant thrashing in her sleep. He also noted that she has abnormal jerking of her left arm that started 1 month ago. She has also had difficulties walking resulting in falls over the last 2 month. On neurological exam, she scores a 22 on the Mini-Mental State Examination. She is noted to have a resting tremor, bradykinesia, cogwheel rigidity, and a shuffling gait. Which the following abnormalities is most likely to be found on the patient's brain autopsy?