Q. A 62-year-old woman has been brought to the emergency department for swelling and severe pain in her right leg for the past 2 days. She has a history of atrial fibrillation and recently initiated warfarin therapy at a dose of 5mg/day a week ago. Her international normalized ratio (INR) is monitored regularly and is normal. Her temperature is 100°F (37.7°C), heart rate is 90/min, respiratory rate is 16/minute, and blood pressure is 130/80 mm of Hg. The physical examination shows erythema and tenderness over her right calf. Doppler ultrasound confirms the presence of a deep vein thrombosis (DVT) in her right lower extremity. What is the most likely pathogenesis behind the development of DVT in this patient?