Q. A 58-year-old man with a known history of chronic lymphocytic leukemia recently underwent a packed red blood cell transfusion due to significant anemia. Almost two hours post-transfusion, he developed sudden onset of chills and fever with a temperature peaking at 103°F. He also complained of lower back pain and generalized discomfort.
On physical examination, he appeared anxious and in distress. His blood pressure was slightly elevated at 150/95 mmHg, his pulse rate was 110 bpm, and he was noted to have mild jaundice. No rash was observed.
On record, his laboratory investigation showed hemoglobin level was 8.2g/dL. His white cell count was 11,000/mm3, and his platelet count was 200,000/mm3. His serum bilirubin was 2.2 mg/dL, and his lactate dehydrogenase (LDH) was 500 U/L. A direct Coombs test was negative.
What is the most appropriate next step in the management of this patient?