Q. A 45-year-old woman has presented to the emergency department with complaints of extreme fatigue and shortness of breath. She reported that these symptoms had progressively worsened over the past two weeks. She also has episodes of dark urine, particularly noticed in the mornings. She denied any significant medical history but mentioned a vague history of similar episodes during childhood. On physical examination, she appeared pale with mild jaundice. A noticeable spleen tip was palpable on deep inspiration. Her heart rate is 105 beats per minute, respiratory rate 20 per minute, blood pressure 115/70 mmHg, and oxygen saturation 95% on room air. Laboratory findings revealed a Hemoglobin level of 7 g/dL, with a Mean Corpuscular Volume (MCV) of 90 fL. The total bilirubin is at 3.0 mg/dL, with a direct bilirubin of 0.6 mg/dL. Her lactate dehydrogenase (LDH) level is at 700 U/L. Peripheral smear revealed spherocytes and no signs of sickle or bite cells. What is the most appropriate next step in the management of this patient?

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