Step 1 - Endocrine System Questions

USMLE / COMLEX - Step 1 > Endocrine System > USMLE/COMLEX 1 - Prep Questions

Q. A 50-year-old male patient presents to the endocrine clinic with complaints of enlarged hands and feet, facial coarsening, and headaches. The patient reports that he has noticed these symptoms for the past few years, and he has also experienced fatigue and joint pain. On physical examination, the patient's hands and feet are enlarged, and there is a prominent supraorbital ridge, enlarged nose, and macroglossia. A diagnosis of acromegaly is made, and the patient is started on octreotide. What is the mechanism of action of octreotide in treating acromegaly in this patient?

Blocking growth hormone receptors, leading to decreased secretion of insulin-like growth factor-1 (IGF-1).
Stimulating growth hormone secretion, leading to decreased IGF-1 levels.
Directly inhibiting the synthesis and release of growth hormone from the pituitary gland.
Increasing the production and release of somatostatin from the hypothalamus, leading to decreased growth hormone release.
Increasing the synthesis and release of insulin, leading to decreased serum levels of growth hormone.
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