Q. A 45-year-old female presents to the endocrinology clinic with a chief complaint of a hard, painless lump in her neck that has been present for the past 6 months. She reports some difficulty breathing and swallowing, and has noticed some hoarseness in her voice. Her past medical history is significant for hypertension. She has no known drug allergies and takes no medications. On examination, a diffuse, hard, non-tender thyroid gland is palpated. Thyroid function reveals low T4 levels with elevated TSH. Fine needle aspiration of the thyroid gland is performed, revealing a dense fibrosis inflammatory infiltrate. Which of the following is the most likely mechanism of disease in this patient's condition?