Q. A 58-year-old male with a history of diabetes and hypertension is recovering from a total hip replacement. He is given Toradol (ketorolac), a nonsteroidal anti-inflammatory drug, for pain. Twenty-four hours later, his urine production decreases. Serum urea nitrogen and creatinine levels rise to 44 mg/dL and 3.1 mg/dL, respectively. What is the effect of this medication on glomerular filtration rate (GFR), renal plasma flow, and filtration fraction?