USMLE/COMLEX 1 - Renal System - Physiology Questions

Physiology > Renal > USMLE/COMLEX 1 - Prep Questions

Q. Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with the development of acute renal failure in patients living in states of effective volume depletion, such as heart failure, cirrhosis, and true volume depletion. This is part of why NSAIDs are avoided in geriatric populations, who often have kidney and excretion issues. What is the mechanism by which NSAIDs are believed to mediate this harmful effect on the kidney?

Increased prostaglandin synthesis constricts preglomerular vessels.
Inhibition of prostaglandin synthesis decreases glomerular capillary permeability.
Inhibition of prostaglandin synthesis decreases preglomerular resistance.
Inhibition of prostaglandin synthesis increases preglomerular resistance.
The drug has direct toxic effects on the renal tubules
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