Q. A 6-year-old girl presents to her pediatrician with persistent weakness. Her mother states this has been ongoing for approximately five to six months, and she has been adding vitamins to her daughter’s diet, since the child does not vary her diet much. The girl has no significant medical history. A physical examination is unremarkable and shows normal blood pressure and no edema. A standard set off labs show hyponatremia, hypokalemia, metabolic alkalosis, and an increased plasma renin level. With these results, the child is sent for a renal biopsy which reveals juxtaglomerular cell hyperplasia. While rare, Bartter’s syndrome is suspected. Bartter’s syndrome results from a defective cotransporter in the thick ascending loop of Henle. Which of the following diuretics acts at the same location as the defect in Bartter’s syndrome?