Cytochrome P450 Pharmacology
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Pharmacologic Principles
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Drug Metabolism (P450)
Q. Which of the following is true regarding the difference between phase 1 and phase 2 reactions?
a
Phase 1 reactions introduce or reveal a functional group to make a substrate more polar. An example is hydroxylation.
b
Phase 1 reactions couple an endogenous, polar moiety to a substrate to make it more polar. An example is hydroxylation.
c
Phase 2 reactions introduce or reveal a functional group to make a substrate more polar. An example is hydroxylation.
d
Phase 2 reactions couple an endogenous, polar moiety to a substrate to make it more polar. An example is hydroxylation.
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