Paraneoplastic Disease, Part 2: Syndromes

Clinical Pathology > Neurology & Psychiatry > Neuro-Oncology

Q. Patient presents with proximal, symmetric weakness in the lower extremities. The patient complains of trouble with standing and climbing stairs; GI upset; and dry mouth. 3,4-diaminopyridine (3,4-DAP) is used along with other medications in the management of the disorder. Which of the following is/are FALSE?

If SOX1 antibody is positive, this patient likely has small cell lung cancer.

P/Q type voltage-gated calcium channel antibody is a key affiliated antibody in this disorder.

Voltage-gated potassium channel antibody is a key affiliated antibody in this disorder.

CRMP-5 is a key affiliated antibody in this disorder.

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