Q. A 24-year-old primigarvida at 34 weeks of gestation, comes to your clinic for a routine prenatal visit. A routine urinalysis indicates the presence of leukocyte esterase, and her urine culture grows Escherichia coli (E. coli) at >100,000 colony-forming units per mL. The culture is highly sensitive to Trimethoprim-sulfamethoxazole (Bactrim-DS). Considering the administration of Trimethoprim-sulfamethoxazole to this patient, which of the following conditions is most likely at an increased risk?