Q. A 28-year-old pregnant woman at 16 weeks gestation presents for her routine prenatal visit. She reports feeling well and has not noticed any symptoms of urinary frequency, urgency, dysuria, flank pain, or fever. On physical examination, her vital signs are stable, and she is afebrile. The abdomen is soft, and non-tender, with a gravid uterus palpable slightly above the pubic symphysis. No costovertebral angle tenderness is noted. Fetal heart tones are heard and are regular. There is no lower extremity edema, and neurological examination is unremarkable. On routine urine analysis, there is evidence of significant bacteriuria. A urine culture confirms the presence of more than 100,000 colony-forming units (CFUs) of Escherichia coli per milliliter. The remainder of her laboratory investigations are within normal limits. What is the most appropriate next step in the management of this patient?