Microtubule Transport (Kinesin)

Cell Biology > Cytoskeleton > Microtubules

Q. A researcher is analyzing the stepwise movement of kinesin along a neuronal microtubule. She observes that one kinesin head releases ADP just before forming a tight interaction with a beta-tubulin subunit on the microtubule. Which of the following best explains the significance of ADP release in this process?

ADP release decreases the affinity of the kinesin head for beta-tubulin

ADP release triggers GTP hydrolysis on beta-tubulin

ADP release allows the kinesin head to tightly bind beta-tubulin

ADP release activates dynactin binding

ADP release promotes detachment of the leading head from the microtubule

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