Microtubule Structure
Cell Biology
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Microtubules
Q. A pharmacologic agent selectively binds to the exchangeable GTP-binding site on beta-tubulin, preventing GTP exchange after hydrolysis. Which of the following effects would most likely result?
a
Stabilization of the microtubule plus end
b
Persistent growth of microtubules from the minus end
c
Increased dynamic instability with rapid microtubule depolymerization
d
Enhanced axonemal dynein ATPase activity
e
Conversion of centrioles from triplets to doublets
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