Cholesterol Homeostasis
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Lipid Metabolism
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Cholesterol
Q. Imagine a mutation in SCAP that prevents its cleavage from SREBP-2. How would this affect cholesterol synthesis?
a
Cholesterol synthesis would not be affected.
b
It would decrease because SREBP-2 would not be able to migrate to the nucleus and upregulate HMG-CoA reductase transcription.
c
It would increase because the SCAP-SREBP-2 complex would be constitutively active and activate HMG-CoA reductase in the cytosol.
d
It would increase because SREBP-2 would not be able to allosterically inhibit HMG-CoA reductase.
e
It would decrease because SREBP-2 would not be able to allosterically inhibit HMG-CoA reductase.
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