Glucagon Secretion & Physiology
Biochemistry
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Integration of Metabolism
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Hormones and Cell Signaling
Q. Which of the following is the correct mechanism of action of glucagon?
a
Glucagon binds GPCR --> alpha subunit of GPCR exchanges GDP for GTP --> alpha subunit activates adenylyl cyclase --> increase in cAMP --> activation of PKA --> PKA phosphorylates downstream enzymes
b
Glucagon binds TKR --> alpha subunit of TKR exchanges GDP for GTP --> alpha subunit activates adenylyl cyclase --> increase in cAMP --> activation of PKA --> PKA phosphorylates downstream enzymes
c
Glucagon binds TKR --> TKR dimerizes --> transphosphorylation of TKR across plasma membrane --> autophosphorylation of cytoplasmic portion of TKR --> activation and amplification of intracellular signal
d
Glucagon binds GPCR --> GPCR dimerizes --> transphosphorylation of GPCR across plasma membrane --> autophosphorylation of cytoplasmic portion of GPCR --> activation and amplification of intracellular signal
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