Excision Repair
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DNA Repair
Q. Which of the following describes the mechanism of action of base-excision repair in humans?
a
DNA glycosylase removes damaged base --> AP endonuclease cleaves DNA backbone and excises damaged moiety --> DNA Pol beta fills gap and ligase seals it
b
UvrA recognizes damaged nucleotide --> UvrA recruits UvrB and UvrC --> Uvr complex cleaves DNA on either side of damage --> Helicase unwinds DNA and releases damaged segment --> DNA Pol epsilon and delta fill gap and ligase seals it
c
RNA Pol stalls at lesion --> CS recognizes stalled RNA Pol and recruits other CS proteins + XP proteins --> Damaged site cleaved --> DNA Pol delta and epsilon fill gap and ligase seals it
d
None of the above
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