Pyruvate Kinase
Biochemistry
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Carbohydrate Metabolism
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Glycolysis
Q. Patients with pyruvate kinase deficiency exhibit hemolytic anemia because:
a
Their red blood cells cannot produce the necessary amount of ATP to sustain homeostasis.
b
Pyruvate is a cofactor for the Na+/K+ pump, which is necessary to maintain osmotic pressure in red blood cells.
c
Phosphoenolpyruvate accumulates in red blood cells, causing cell death.
d
Abnormal pyruvate kinase damages the cell membrane, lysing the cell.
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