Plasma Osmolality

We calculate plasma osmolality to measure the body's electrolyte-water balance.
Plasma Osmolality =osmol/kgH2O = 2 * [Na+] [mEq/L] + Glucose (mg/dL)/18 + BUN (mg/dL)/2.8
  • * Osmolality vs Osmolarity:
    • Osmolality = the number of osmoles (Osm) of solute per kilogram of solvent (osmol/kg or Osm/kg)
    • Independent of temperature and pressure
  • Osmolarity = the number of osmoles of solute per liter (L) of solution (osmol/L or Osm/L).
    • Affected by changes in water content, temperature and pressure