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Rosettes and Pseudorosettes
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Rosettes and Pseudorosettes

Histopathology of Rosettes and Pseudorosettes
  • Homer Wright Rosettes
    • Originally described in neuroblastoma. Notably, found in medulloblastoma and other PNETs and also in pineoblastoma.
    • Cluster of cells surround a central lumen filled with a meshwork of fibers (central neuropil-region).
    • Pineocytomatous and Neurocytic rosettes are similar in appearance but are larger and more irregular.
  • Flexner-Wintersteiner Rosettes
    • Originally described in retinoblastoma. Also found in pineoblastoma and medulloepithelioma.
    • Cluster of cells project short cytoplasmic projections into a central lumen.
  • True Ependymal Rosettes
    • Despite their name, they are uncommon in ependymoma.
    • Cells surround a central lumen with NO fiber-rich central neuropil (NO significant central cytoplasmic projections).
  • Perivascular Pseudorosettes
    • Commonly found ependymoma.
    • Cells surround a central vessel (rather than a lumen). Their tapered cellular processes radiate around the vessel.
References
  • Adesina, Adekunle M., Tarik Tihan, Christine E. Fuller, and Tina Young Poussaint. Atlas of Pediatric Brain Tumors. Springer, 2016.
  • Orkin, Stuart H., David E. Fisher, A. Thomas Look, Samuel Lux, David Ginsburg, and David G. Nathan. Oncology of Infancy and Childhood E-Book. Elsevier Health Sciences, 2009.
  • Prayson, Richard A., and Mark L. Cohen. Practical Differential Diagnosis in Surgical Neuropathology. Springer Science & Business Media, 2000.
  • Wippold, F. J., and A. Perry. “Neuropathology for the Neuroradiologist: Rosettes and Pseudorosettes.” American Journal of Neuroradiology 27, no. 3 (March 1, 2006): 488–92.
Image References
  • Homer Wright Rosette
    • Institute, Dr Maria Tsokos, National Cancer. Shown Is a Microscopic View of a Typical Neuroblastoma with Rosette Formation. Magnified X40. December 1993. http://visualsonline.cancer.gov/details.cfm?imageid=2593. https://commons.wikimedia.org/wiki/File:Neuroblastoma_rosettes.jpg.
  • Flexner-Wintersteiner Rosette
    • Pathology, The Armed Forces Institute of. ADRENAL GLAND: RETINOBLASTOMA. [object HTMLTableCellElement]. PEIR Digital Library (Pathology image database). Image
      413737. Image and description are from the AFIP Atlas of Tumor Pathology.
https://commons.wikimedia.org/wiki/File:Retinoblastoma_rosette.jpg.
  • True Ependymal Rosette
    • Nephron. English: Micrograph of an Ependymoma. H&E Stain. [object HTMLTableCellElement]. Own work. https://commons.wikimedia.org/wiki/File:Ependymoma_intermed_mag.jpg.
  • Perivascular Pseudorosettes
    • Jensflorian. English: Ependymoma Showing True Ependymal Rosettes besides Perivascular Pseudorosettes. October 22, 2010. Own work. https://commons.wikimedia.org/wiki/File:Ependymoma_true_ependymal_rosettes_and_pseudorosettes.jpg.