Paraneoplastic Cerebellar Degeneration (PCD)
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Clincial Manifestations
- Cerebellar Signs and Symptoms:
- Trunk and limb ataxia
- Dysarthria
- Diplopia
- Vertigo
- Rapidly progressive disorder
- Disability within days to weeks
Antibodies
- Anti-Yo antibody (aka anti-Purkinje antibody)
- The is the most commonly associated antibody (the majority of cases).
- Associated with breast and gynecological malignancies.
- Anti-Ri (ANNA-2)
- Associated with breast and gynecological malignancies.
- Anit-Hu
- Associated with small cell lung cancer
Malignancies
- Gynecologic malignancies
- Ovarian cancer was the first discovered associated cancer, thus the disorder is classically tied to this malignancy.
- Breast cancer
- Small cell lung cancer
- Hodgkin’s lymphoma
References
- Fanous, Ibrahim, and Patrick Dillon. “Paraneoplastic Neurological Complications of Breast Cancer.” Experimental Hematology & Oncology 5 (October 24, 2016). https://doi.org/10.1186/s40164-016-0058-x.
- Samuels, Martin A., Allan H. Ropper, and Joshua Klein. Adams and Victor’s Principles of Neurology 10th Edition. McGraw-Hill Education, 2014.
- Shams’ili, Setareh, Joost Grefkens, Bertie de Leeuw, Martin van den Bent, Herbert Hooijkaas, Bronno van der Holt, Charles Vecht, and Peter Sillevis Smitt. “Paraneoplastic Cerebellar Degeneration Associated with Antineuronal Antibodies: Analysis of 50 Patients.” Brain: A Journal of Neurology 126, no. Pt 6 (June 2003): 1409–18.