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Dysembryoplastic Neuroepithelial Tumor (DNET)
Dysembryoplastic Neuroepithelial Tumor (DNET)
- Superficial, typically temporal lobe-located glioneuronal (mixed neuronal-glial) tumor that tends to present in male patients < 20 y.o. and manifest with refractory partial-onset seizures (Differential includes ganglioglioma/gangliocytoma).
- They typically localize to the cortical/juxtacortical region of the temporal lobe.
- They are generally benign (G1) and do not cause mass effect or enhance.
- Surgical resection often helps in seizure management.
- Histopathology characteristically demonstrates floating neurons (a mature ganglion cell in a pool of mucin) and also oligodendroglia-like cells (fried-egg appearance).
References
- Adesina, Adekunle M., Tarik Tihan, Christine E. Fuller, and Tina Young Poussaint. Atlas of Pediatric Brain Tumors. Springer, 2016.
- Gray, Frangoise, Charles Duyckaerts, and Umberto De Girolami. Escourolle and Poirier’s Manual of Basic Neuropathology. OUP USA, 2013.
- Tonn, Jörg-Christian, Manfred Westphal, and J. T. Rutka. Oncology of CNS Tumors. Springer Science & Business Media, 2010.
- Yachnis, Anthony T., and Marie L. Rivera-Zengotita. Neuropathology E-Book: A Volume in the High Yield Pathology Series. Elsevier Health Sciences, 2012.
Image Reference
- Histopathology: Floating Neurons and Oligodendroglia-like Cells
- Jensflorian. English: Dysembryoblastic Neuroepithelial Tumor (DNET), MAP2 Immunohistochemistry High Magnification, FFPE Specimen. April 14, 2015. Own work. https://commons.wikimedia.org/wiki/File:DNET_MAP-high_power.jpg.