DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms)

• DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) syndrome is a complex, broad spectrum syndrome with clinical manifestations that appear 2 ~ 8 weeks after introduction of the offending agent.

• Fever
• Eosiniphilic rash: urticaria, maculopapular eruption (vesicles, bullae, purpura, pustules)
• Eosinophilic leukocytosis
• Pancytopenia
• Abnormal liver function tests
• Visceral involvement
• Hepatitis, pneumonitis, myocarditis, pericarditis, nephritis, and colitis.

• ~ 10%

• Antimicrobials
• Dapsone
• Minocycline
• Penicillin
• Sulfamethoxazole/Trimethoprim
• TB antimicrobials
• Antiepileptic drugs
• Phenytoin
• Phenobarbital
• Allopurinol
• NSAIDs

See: Choudhary S, McLeod M, Torchia D, Romanelli P. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome. The Journal of Clinical and Aesthetic Dermatology. 2013;6(6):31-37.