Choroid Plexus Papilloma
Choroid Plexus Papilloma
- Choroid plexus papilloma is a benign (G1), typically childhood-onset, intraventricular tumor.
- It is globular (or cauliflower-like) macroscopically and well-demarcated and usually arises from the lateral ventricle (patients < 20 yo) or fourth ventricle (any age).
- Histopathologically they demonstrate epithelial cells lining delicate fibrovascular cores in a papillary (nipple-shaped) pattern.
- Typically demonstrate heterogenous signal intensity and contrast enhancement on MRI.
- Can easily be mistaken for choroid plexus hypertrophy.
- Choroid plexus papilloma has a good prognosis whereas choroid plexus carcinoma has a poor prognosis.
- Choroid plexus carcinoma (which typically occurs in young children) demonstrates malignant pathology with invasion of brain tissue and hemorrhage/necrosis and thus a poor prognosis.
- Choroid plexus papilloma is ~ 5 times more common than choroid plexus carcinoma.
References
- Adesina, Adekunle M., Tarik Tihan, Christine E. Fuller, and Tina Young Poussaint. Atlas of Pediatric Brain Tumors. Springer, 2016.
- Gray, Frangoise, Charles Duyckaerts, and Umberto De Girolami. Escourolle and Poirier’s Manual of Basic Neuropathology. OUP USA, 2013.
- Sethi, Divya, Rashmi Arora, Ketan Garg, and Parul Tanwar. “Choroid Plexus Papilloma.” Asian Journal of Neurosurgery 12, no. 1 (2017): 139–41. https://doi.org/10.4103/1793-5482.153501.
- Tonn, Jörg-Christian, Manfred Westphal, and J. T. Rutka. Oncology of CNS Tumors. Springer Science & Business Media, 2010.
- Yachnis, Anthony T., and Marie L. Rivera-Zengotita. Neuropathology E-Book: A Volume in the High Yield Pathology Series. Elsevier Health Sciences, 2012.
Image References
- Low-mag choroid plexus papilloma histopathological slide (background)
- Nephron. English: Micrograph of a Choroid Plexus Papilloma. H&E Stain. [object HTMLTableCellElement]. Own work. https://commons.wikimedia.org/wiki/File:Choroid_plexus_papilloma_micrograph.jpg.
- High-mag choroid plexus papilloma histopahtological slide (right-side of image, foreground)
- MD, Martin Hasselblatt. Photomicrograph of Hematoxylin-Eosin Stained Section of a Choroid Plexus Papilloma (Grade I WHO)at 400x Magnification. Image Taken Using an Olympus Microscope and Analysis-Imaging Software on 10-24-2006 by Martin Hasselblatt MD. October 24, 2006. Own work. https://commons.wikimedia.org/wiki/File:Choroidplexuspapilloma_HE400x.png.