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Microscopic polyangiitis
Microscopic polyangiitis
Characterized by necrotizing pauci-immune inflammation without granulomas.
Renal involvement is associated with glomerulonephritis and rapid progression to renal failure.
Purpuric rash is common.
The lungs are less commonly affected, but, when they are, alveolar hemorrhage and fibrosis can be serious.
Microscopic polyangiitis usually develops in patients 50-60 years old.