A nerve fiber layer, meaning that it is cell sparse and predominantly comprises axons and dendritic processes.
Layer II
The External Granular Layer
Contains non-pyramidal cells 5-15 micrometers, and relatively few, small pyramidal cells.
Layer III
The External Pyramidal Layer
Predominantly contains pyramidal cells of varying sizes: 10 to 80 micrometers. Also, layer III is sparsely populated with non-pyramidal cells.
Layer IV
The Internal Granular Layer
Densely packed with non-pyramidal cells.
Contains the horizontally oriented external band of Baillarger: a prominent thalamocortical nerve fiber layer. In the primary visual cortex, this nerve fiber band is called the line of Gennari.
Layer V
Internal Pyramidal (or ganglionic) Layer
Contains the largest pyramidal cells, most notably the Betz cells of the primary motor cortex – the major cortical motor neurons.
The horizontally-oriented internal band of Baillarger lies deep within this layer.
Layer VI
The Multiform (or fusiform) Layer
Contains a wide variety of pyramidal and non-pyramidal cells.