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Carbon Monoxide Poisoning
Axial FLAIR MRI sequence showing bilateral globus pallidus hyperintensity (T2 hyperintensity). Abnormality highlighted.
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Carbon Monoxide Poisoning

Carbon monoxide poisoning is the most widely known cause of bilateral globus pallidus necrosis.
Other important causes include toxic drug exposure, such as from:
  • MDMA (methylenedioxymethamphetamine)
  • Cocaine
  • Opiates
  • Cyanide
See also: Eye-of-the-Tiger sign, found primarily in Pantothenate kinase-2-associated neurodegeneration (PKAN) (aka Hallervorden-Spatz syndrome) - a form of neurodegeneration with brain iron accumulation (NBIA).

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