Tetracyclines: Tetracycline, Doxycycline, and Minocycline
– Acne
– Doxycycline is effective against
MRSA infection
–
Borrelia burgdorferi
–
Mycoplasm pneumoniae
–
Rickettsia
–
Chlamydiae
Tetracyclines accumulate intracellularly, which accounts for their ability to act on intracellular bacteria.
– Bind the 30S subunit
Prevents aminoactyl-tRNA attachment and, therefore, block an early step in protein synthesis.
– Gastrointestinal discomfort
– Photosensitivity
– In
children these drugs can cause
tooth discoloration and bone growth inhibition
–
Contraindicated in pregnancy
–
Do not take with milk, antacids, or iron, which can interfere with their absorption in the gastrointestinal tract.
Glycycline: Tigecycline
Broad-spectrum effects
– Gram-negative bacteria
– Gram-positive bacteria
– Mycobacteria
– MRSA
– VRE
– Binds the 30S subunit
– Gastrointestinal discomfort
