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Tetracyclines & Glycycline
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Tetracyclines & Glycycline

Tetracyclines: Tetracycline, Doxycycline, and Minocycline
  • Most common uses
– Acne – Doxycycline is effective against MRSA infection – Borrelia burgdorferi – Mycoplasm pneumoniae – Rickettsia – Chlamydiae
Tetracyclines accumulate intracellularly, which accounts for their ability to act on intracellular bacteria.
  • Mechanism of Action
– Bind the 30S subunit Prevents aminoactyl-tRNA attachment and, therefore, block an early step in protein synthesis.
  • Adverse effects
– Gastrointestinal discomfort – Photosensitivity – In children these drugs can cause tooth discoloration and bone growth inhibition – Contraindicated in pregnancy – Do not take with milk, antacids, or iron, which can interfere with their absorption in the gastrointestinal tract.
Glycycline: Tigecycline
  • Most common uses
Broad-spectrum effects – Gram-negative bacteria – Gram-positive bacteria – Mycobacteria – MRSA – VRE
  • Mechanism of Action
– Binds the 30S subunit
  • Adverse effects
– Gastrointestinal discomfort

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