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Macrolides
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Macrolides

Macrolides: Azithromycin, Erythromycin, and Clarithromycin
  • Most common uses
Broad-spectrum – Gram-positive bacteria – Neisseria – Legionella – Mycoplasma – Chlamydiae – Treponema – Clarithromycin and Azithromycin are effective against some Mycobacteria.
  • Mechanism of Action
– Binds the 50S subunit Block translocation and protein synthesis
  • Adverse effects
– Gastrointestinal upset due to increased motility – QT prolongation – Hepatotoxicity

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