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Macrolides
Macrolides: Azithromycin, Erythromycin, and Clarithromycin
Most common uses
Broad-spectrum – Gram-positive bacteria –
Neisseria
–
Legionella
–
Mycoplasma
–
Chlamydiae
–
Treponema
– Clarithromycin and Azithromycin are effective against some
Mycobacteria
.
Mechanism of Action
– Binds the 50S subunit Block translocation and protein synthesis
Adverse effects
– Gastrointestinal upset due to increased motility –
QT prolongation
– Hepatotoxicity
Related Tutorials
Antibiotics Mechanisms
Antibiotics: Ribosomes