Aggregatibacter

This genus comprises species that were formerly classified as Actinobacillus or Haemophilus* – Be aware that some authors continue to refer to these species by their former genus names. Aggregatibacter actinomycetemcomitans is often found with Actinomyces* in mixed infections, hence its name. – Colonies are described as star-shaped or like cigars crossing. – It is associated with subacute endocarditis of damaged valves. – Some strains cause localized aggressive periodontitis; toxins, including leukotoxins, cause significant damage to the tissues of the oral cavity. Aggregatibacter aphrophilus* is also associated with endocarditis of damaged valves. – This bacteria has also been found in brain abscesses in children with congenital heart disease. Endocarditis caused by Aggregatibacter* species can be treated with cephalosporins

• Periodontitis treatment includes biofilm debridement and administration of doxycycline or other antibiotics.

Brain abscesses caused by Aggregatibacter aphrophilus* infection can be treated with meropenem.