This genus comprises species that were formerly classified as Actinobacillus
or Haemophilus*
– Be aware that some authors continue to refer to these species by their former genus names.
Aggregatibacter actinomycetemcomitans is often found with Actinomyces* in mixed infections, hence its name.
– Colonies are described as star-shaped or like cigars crossing.
– It is associated with subacute endocarditis of damaged valves.
– Some strains cause localized aggressive periodontitis; toxins, including leukotoxins, cause significant damage to the tissues of the oral cavity.
Aggregatibacter aphrophilus* is also associated with endocarditis of damaged valves.
– This bacteria has also been found in brain abscesses in children with congenital heart disease.
Endocarditis caused by Aggregatibacter* species can be treated with
cephalosporins
- Periodontitis treatment includes biofilm debridement and administration of doxycycline or other antibiotics.
Brain abscesses caused by Aggregatibacter aphrophilus* infection can be treated with
meropenem.
