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Rifamycin
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Rifamycin

Rifamycins: Rifampin and Rifabutin
  • Most common uses
– Mycobacteria – Rfabutin is particularly active against Myocbacterium avium
  • Mechanism of Action
– Inhibit bacterial RNA synthesis
  • Mechanism of Action
– Resistance appears more likely to develop with monotherapy
  • Adverse effects
– Reddish-brown hue to the urine, saliva, tears, and other bodily fluids. – Gastrointestinal upset – Rash – Headache

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