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Quinolone (Nalidixic Acid)

Quinolone (Nalidixic Acid)

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Quinolone: Nalidixic acid
  • Most common uses
– Gram-negative bacteria Was particularly useful against urinary tract infections prior to widespread resistance.
  • Mechanism of Action
– Inhibits DNA replication via inhibition of topoisomerase type II (aka, gyrase) in Gram-negative bacteria
  • Adverse effects
– Nausea and vomiting – Visual changes – Headache – Rash

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