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Pathogen Dissemination & Immune Evasion

Dissemination:

Pathogens enter through a breach in the epithelia or mucosa.
Inside the host, some pathogens infect peripheral nerves and travel along their axons.

– For example, the Varicella-zoster virus, which is responsible for chickenpox, can lead to serious central nervous system complications, especially upon later reactivation. – Other pathogens travel within macrophages and other cells, or move freely in the plasma.

Dissemination via the lymph and blood vessels can lead to systemic infections or organ-based pathologies.
Some pathogens, especially neurotropic viruses and certain parasites, are tissue trophic.

– Infect specific tissues, are therefore associated with characteristic disease patterns.

Pathogen Dissemination & Immune Evasion

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