Aminoglycosides

Aminoglycosides: Gentamycin, Neomycin, Amikacin, Tobramycin, and, Streptomycin

– Gram-negative infections – Not effective against anaerobes – Often used synergistically with beta-lactams

– Bind the 30S subunit Causes misreading of bacterial mRNA and blocking translocation

– Enzymatic inactivation of the antibiotics

– Nephrotoxicity – Neuromuscular blockade – Ototoxicity – Contraindicated in pregnancy (teratogens)