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Acyclovir
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Acyclovir

Acyclovir
  • Administered Intravenously, orally, or topically
  • It is commonly used to treat infections caused by
– Herpes virus 1 and Herpes Virus 2 – Varicella-zoster virus (the cause of chickenpox) – Herpes-zoster virus (the reactivated VZV, and is the cause of shingles)
  • Acyclovir is a guanosine analogue
– Inserts acyclo-GTP (acyclovir triphosphate, a derivative of acyclovir) into actively replicating viral chains and stopping their growth It is activated by virus-encoded thymidine kinase
  • At high doses, it can be nephrotoxic and neurotoxic

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