embryology of the female external genitalia
Aka, the vulva
During gestation, development is influenced by estrogen from the placenta, and, possibly, the developing fetal ovaries.
Weeks 3-4
Undifferentiated primordial genitalia
During weeks 3-4 the genital tubercle, which is the precursor to the clitoris, emerges.
- Recall that the cloacal membrane covers the opening of the cloaca prior to separation of the distal urinary and digestive tracts.
- Primordia of the genital tubercle borders the membrane.
- Anterior fusion of the primordia forms the definitive genital tubercle.
- Posteriorly, the unfused portion gives rise to the genital (aka, urogenital) folds, which enclose the cloacal membrane.
- Lateral to the folds the genital swellings (aka, labioscrotal swellings) take form.
Weeks 7-9
Elongation of the urorectal septum divided the cloaca into urogenital and digestive tracts.
- By this stage, the genital tubercle and folds are enlarged.
- Perineal body lies posterior to the genital folds
- Perineal body is where the urorectal septum connected to the cloacal membrane, it separates the genital folds from the anal folds.
- Aka, the central tendon of the perineum
- Division of the cloacal membrane gives rise to the urogenital membrane, enclosed by the genital folds, and, the anal membrane, enclosed by the anal folds.
- By the end of week nine, the urogenital and anal membranes disappear.
- Genital tubercle is now the glans of the clitoris.
- Urogenital groove appears where urogenital membrane was.
- Anus appears where the anal membrane was.
- The area between the urogenital groove and anus is the perineum.
Weeks 11-12
Final stages of vulva formation.
- Glans of the clitoris recedes.
- The genital folds give rise to the labia minora
- Prepuce of labia minora covers body of clitoris
- Vestibule of vagina is area between right and left labia minora; urethra and vagina open to vestibule.
- The genital swellings give rise to the labia majora
- Anterior fusion = mons pubis
- Posterior fusion = posterior labial commissure
- Deeper structures
Clitoris
Bulb of the vestibule
- Deep to clitoral crura and vestibule of the vagina.