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One Carbon Metabolism
TETRAHYDROFOLATE (THF)
  • Metabolically active derivate of folate (B vitamin)
  • Folate sources: Vegetables
– Broccoli, spinach, peas, beans, beets and sunflower seeds
  • THF carries: methyl, methylene, methenyl and formyl group
  • THF carries carbons on N5 and/or N10 of its pteridine ring
  • Dihydrofolate reductase: Folate --> Dihydrofolate --> Tetrahydrofolate
(each step requires NADPH + H+)
  • 3 major pathways: amino acid synthesis, purine synthesis & thymidine synthesis
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One Carbon Metabolism

One Carbon Metabolism: Overview of the Biosynthesis of Small Molecules
Transfer single carbon atoms between molecules in metabolic pathways:
  • Nucleotide synthesis (purines and pyrimidines)
  • Neurotransmitter synthesis
  • Amino acid synthesis
  • Epinephrine synthesis
  • DNA Methylation